H2N2V1, 1968, Analysis, bibRecord, 000050

Genetic evolution of the neuraminidase of influenza A (H3N2) viruses from 1968 to 2009 and its correspondence to haemagglutinin evolution

Identifieur interne : 000050 ( 1968/Analysis ); précédent : 000049; suivant : 000051

Genetic evolution of the neuraminidase of influenza A (H3N2) viruses from 1968 to 2009 and its correspondence to haemagglutinin evolution

Auteurs : Kim B. Westgeest [Pays-Bas] ; Miranda De Graaf [Pays-Bas, Royaume-Uni] ; Mathieu Fourment [Singapour] ; Theo M. Bestebroer [Pays-Bas] ; Ruud Van Beek [Pays-Bas] ; Monique I. J. Spronken [Pays-Bas] ; Jan C. De Jong [Pays-Bas] ; Guus F. Rimmelzwaan [Pays-Bas] ; Colin A. Russell [Royaume-Uni, États-Unis] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Gavin J. D. Smith [Singapour] ; Derek J. Smith [Pays-Bas, Royaume-Uni, États-Unis] ; Ron A. M. Fouchier [Pays-Bas]

Source :

The Journal of General Virology [ 0022-1317 ] ; 2012.

RBID : PMC:3542130

Abstract

Each year, influenza viruses cause epidemics by evading pre-existing humoral immunity through mutations in the major glycoproteins: the haemagglutinin (HA) and the neuraminidase (NA). In 2004, the antigenic evolution of HA of human influenza A (H3N2) viruses was mapped (Smith et al., Science305, 371–376, 2004) from its introduction in humans in 1968 until 2003. The current study focused on the genetic evolution of NA and compared it with HA using the dataset of Smith and colleagues, updated to the epidemic of the 2009/2010 season. Phylogenetic trees and genetic maps were constructed to visualize the genetic evolution of NA and HA. The results revealed multiple reassortment events over the years. Overall rates of evolutionary change were lower for NA than for HA1 at the nucleotide level. Selection pressures were estimated, revealing an abundance of negatively selected sites and sparse positively selected sites. The differences found between the evolution of NA and HA1 warrant further analysis of the evolution of NA at the phenotypic level, as has been done previously for HA.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542130

DOI: 10.1099/vir.0.043059-0
PubMed: 22718569
PubMed Central: 3542130

Affiliations:

Links to Exploration step

PMC:3542130

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Each year, influenza viruses cause epidemics by evading pre-existing humoral immunity through mutations in the major glycoproteins: the haemagglutinin (HA) and the neuraminidase (NA). In 2004, the antigenic evolution of HA of human influenza A (H3N2) viruses was mapped (Smith <italic>et al.</italic>
, <italic>Science</italic>
<bold>305</bold>
, 371–376, 2004) from its introduction in humans in 1968 until 2003. The current study focused on the genetic evolution of NA and compared it with HA using the dataset of Smith and colleagues, updated to the epidemic of the 2009/2010 season. Phylogenetic trees and genetic maps were constructed to visualize the genetic evolution of NA and HA. The results revealed multiple reassortment events over the years. Overall rates of evolutionary change were lower for NA than for HA1 at the nucleotide level. Selection pressures were estimated, revealing an abundance of negatively selected sites and sparse positively selected sites. The differences found between the evolution of NA and HA1 warrant further analysis of the evolution of NA at the phenotypic level, as has been done previously for HA.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Singapour</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Hollande-Méridionale</li>
<li>Maryland</li>
</region>
<settlement><li>Cambridge</li>
<li>Rotterdam</li>
</settlement>
<orgName><li>Université de Cambridge</li>
</orgName>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Westgeest, Kim B" sort="Westgeest, Kim B" uniqKey="Westgeest K" first="Kim B." last="Westgeest">Kim B. Westgeest</name>
</region>
<name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M." last="Bestebroer">Theo M. Bestebroer</name>
<name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name>
<name sortKey="De Jong, Jan C" sort="De Jong, Jan C" uniqKey="De Jong J" first="Jan C." last="De Jong">Jan C. De Jong</name>
<name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
<name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name>
<name sortKey="Spronken, Monique I J" sort="Spronken, Monique I J" uniqKey="Spronken M" first="Monique I. J." last="Spronken">Monique I. J. Spronken</name>
<name sortKey="Van Beek, Ruud" sort="Van Beek, Ruud" uniqKey="Van Beek R" first="Ruud" last="Van Beek">Ruud Van Beek</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name>
</region>
<name sortKey="Russell, Colin A" sort="Russell, Colin A" uniqKey="Russell C" first="Colin A." last="Russell">Colin A. Russell</name>
<name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name>
</country>
<country name="Singapour"><noRegion><name sortKey="Fourment, Mathieu" sort="Fourment, Mathieu" uniqKey="Fourment M" first="Mathieu" last="Fourment">Mathieu Fourment</name>
</noRegion>
<name sortKey="Smith, Gavin J D" sort="Smith, Gavin J D" uniqKey="Smith G" first="Gavin J. D." last="Smith">Gavin J. D. Smith</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Russell, Colin A" sort="Russell, Colin A" uniqKey="Russell C" first="Colin A." last="Russell">Colin A. Russell</name>
</region>
<name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name>
</country>
</tree>
</affiliations>
</record>

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Genetic evolution of the neuraminidase of influenza A (H3N2) viruses from 1968 to 2009 and its correspondence to haemagglutinin evolution

Genetic evolution of the neuraminidase of influenza A (H3N2) viruses from 1968 to 2009 and its correspondence to haemagglutinin evolution

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